Familial Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax.

Familial spontaneous pneumothorax.

In a three generation family with 27 members we examined a relationship could be found between spontaneous pneumothorax and HLA-haplotypes, alpha 1-antitrypsin phenotypes or concentration or lung volumes and ventilatory capacity. Eight individuals in the family suffered from spontaneous pneumothorax. No relationship with the investigated markers could be found in this informative family. All pa...

Familial spontaneous pneumothorax.

Introduction Spontaneous pneumothorax usually occurs sporadically in healthy young adults and the cause is often unknown. Kjaergaard (1935), and Brock (1948) favoured the presence of hereditary congenital lung cysts, which by rupturing, produced a pneumothorax. Familial cases of spontaneous pneumothorax have been described several times since the original description by Faber (1921). The occurr...

Familial spontaneous pneumothorax and HLA antigens.

Twenty-three members of a family in which six persons had repeated spontaneous pneumothorces were studied for physical, chemical and genetic markers of this disease. A relationship between the HLA haplotype A2, B40, the alpha 1, antitrypsin phenotype M1 M2 and the occurrence of spontaneous pneumothorax was suggested in this family.

Familial spontaneous pneumothorax in two adult siblings with Marfan syndrome.

A 21-year-old adult with previously diagnosed Marfan syndrome (MS) was admitted to our hospital complaining of chest pains that resulted from a complete left spontaneous pneumothorax (SP). A chest roentgenogram showed a 70% pneumothorax on the left side. Because for 8 days chest tube drainage did not ameliorate the air leak, and also because a computed tomography (CT) scan showed many cystic op...